Biotechnology HPC Software Applications Institute (BHSAI)

BHSAI News

June 2019

Key staff representing our organization at this year’s Pentagon Lab Day! From left: Ms. Samantha Hornby (BHSAI), Mr. Nate Fisher (MISL), Mr. Geoff Miller (MMSV), and then-Director COL Gina Adam.
28 June, 2019 TATRC Participates in its 3rd Pentagon Lab Day

Team TATRC had the honor and pleasure of being a part of the third biennial Department of Defense Lab Day 2019 held at the Pentagon Courtyard hosted by the Under Secretary of Defense for Research and Engineering (USD(R&E)) which took place on 25 April.

Read the Article

A computational approach to bridge in vitro and in vivo experiments, both within and across species. Data from Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System (TG-GATEs) were used to identify key genes (modules) associated with liver injuries in rats in vivo, which were validated and further tested in rat in vitro and in human in vitro studies.
28 June, 2019 BHSAI Scientists Mine Big Data to Identify Sets of Genes Predictive of Liver and Kidney Injuries

The goal of predictive toxicology and ultimately personalized medicine is to use your own cells to customize the best treatment for you. For this to work, test tube results (in vitro) need to have some connection with the toxic response in the human body (in vivo) so that the physician can correctly interpret the results and start treatment.

Read the Article

A paratrooper savors his morning cup of coffee between firing missions at Grafenwohr, Germany where the 4-319 Field Artillery of the 173d Airborne Brigade is training. John Hall/Army
12 June, 2019 US Army scientists improving alertness optimization app with caffeine algorithm

Short on rest but no time to nap? The U.S. Army has your quick fix caffeine map.

A team of Army researchers, including Jaques Reifman, a senior research scientist at the Army Medical Research and Development Command, has built a “caffeine optimization app,” known as 2B-Alert, that notifies its users when they should drink a cup-o-joe.

Read the Article

March 2019

During a vaccine clinical trial, immunological data are collected at several time points following vaccination, prior to infection. Data from each subject are then fed into an AI-based model to make an individualized prediction of protection, which is compared with the clinically observed protection status of that subject. An accurate predictive model can be used to determine what combination of immune responses is most responsible for protection, providing a basis for guiding future vaccine design efforts.
31 March, 2019 BHSAI Uses Artificial Intelligence (AI) Methods to Assess Vaccine-Induced Immune Responses

Vaccines are an essential component of Force Health Protection, particularly for Service members deployed overseas where they may be exposed to infectious diseases, such as malaria and dengue fever, or newly emergent outbreaks, such as Ebola or Zika virus.

Read the Article

December 2018

coffee graphic
31 December, 2018 BHSAI’s New Algorithm Could Help Reduce the Risk of Heat Injuries

We often overestimate our ability to stay active in scorching weather—hence, our surprise when we hear of people dying of heat stroke during a summer heat wave.

Read the Article

November 2018

coffee graphic
8 November, 2018 A New Tool for Sleep-Deprived Soldiers to Optimize and Restore Alertness When It Matters Most

Sleep deprivation is common among military personnel. Roughly 40% sleep less than 5 hours a night, even though they need 7 to 8 hours to recover mental acuity. Yet, Warfighters often need to be vigilant while deprived of sleep.

Read the Article

July 2018

coffee graaphic
24 July, 2018 After 10 Years Studying Sleep, the U.S. Military Just Revealed Something Eye-Opening About Caffeine

We've seen over and over that there are tremendous health benefits to drinking coffee--even a heck of a lot of coffee--including substantial increases in lifespan.

But if you think American office workers are especially sleep-deprived and powered by caffeine, it turns out we've got nothing on the U.S. military.

Read the Article

coffee graaphic
23 July, 2018 US Army App To Reveal How Much Coffee You Need

Sleep deprivation in the forces is not uncommon, so determining the ideal amount of caffeine to consume for maximum efficiency could be key in reducing accidents.

Now the US Army and the US Department of Defense have developed software which could provide answers.

Read the Article

 A siphon coffee maker pours a jolting cup at Black Ivory Coffee in Ban Taklang village in Thailand. Photo: Taylor Weidman/Bloomberg News
20 July, 2018 What’s Your Ideal Caffeine Fix? An Algorithm Can Tell You

If you need to wake up, caffeine can help. But for the optimal jolt, how much and when?

The U.S. Army and the Department of Defense have developed an algorithm to answer that question. It’s of critical interest because soldiers may go for days without getting enough sleep or, in some cases, any sleep at all.

A perfectly timed and ideal portion of caffeine can fend off fatigue that might otherwise jeopardize a mission or put lives at risk.

Read the Article

June 2018

The ADMET predictions result page. The 15 ADMET predictions for each query molecule are presented on a separate row. High confidence predictions are shown in solid colors and low confidence predictions are shown in striped. The website can be publically accessed at https://vnnadmet.bhsai.org
29 June, 2018 BHSAI Develops a Website for Predicting Pharmacological & Toxicological Properties of Molecules Not Studied Before

Military medicine is facing ever increasing and greater challenges in maintaining Force Health Protection by diagnosing and treating Warfighters exposed to diseases and hazardous chemicals.

Read the Article

Coffee Brewing
14 June, 2018 How Much Caffeine Do You Need to Function? A New App May Help

Researchers divide us into three types of “caffeine sensitivity.” Now, an app with a new algorithm may be able to calculate the perfect caffeine dose for everyone.

Why do some people have laser focus after one cup of coffee while it seems others have to keep a pot brewing all day to just stay awake?

According to a report by Dr. J.W. Langer, a science journalist, genetic factors determine our reaction to caffeine.

Read the Article

Cup of Coffee
13 June, 2018 Algorithm Shows Right Amount Of Coffee To Drink For Peak Alertness

Drinking the right amount of coffee can be a tricky task. If you don’t drink enough, you could sleepwalk through the day, but if you drink too much, you can become wired and lightheaded.

Those days may be behind us.

Read the Article

Coffee
11 June, 2018 App tells you best time to drink coffee

Your coffeemaker may seem like your best friend when you stumble out of bed, but is first thing in the morning really the best time to have that jolt of caffeine?

U.S. Army researchers have developed a smartphone app that can tell you by using algorithms and sleep pattern information to determine how much caffeine you should have for optimal alertness and when you should consume it.

Read the Article

Coffee
7 June, 2018 How to Time Your Caffeine Consumption and Maximize Alertness

Have you ever found yourself chugging coffee to stay up late studying, but then when it’s time for the exam, your mind is foggy with fatigue? Researchers from the U.S. Army have developed an algorithm that can predict the energy peaks and valleys that come from drinking caffeine, and in turn, created a web-based tool that helps you predict how alert you can expect to be based on your own sleep schedule and coffee habits.

Read the Article

Coffee
7 June, 2018 Are You Drinking Coffee Right? Army Scientists Create Algorithm for the Perfect Caffeine Hit

Perhaps you drink coffee for the smooth, rich taste. Or maybe you crave the surge of energy from a solid caffeine hit. However you take your cup of joe, the stimulant can run riot through your system—speeding up your heartbeat and even giving you the shakes.

But, when taken at just the right time, in just the right dose, coffee can keep you alert when you’re short on shut-eye. Now, U.S. Army scientists have developed an algorithm to harness the power of the nation’s favorite tiredness-targeting stimulant.

Read the Article

Coffee
6 June, 2018 New Algorithm-based Caffeine Dosing Strategy Provides Customized Guidance to Counter Sleep Loss

According to a recent study, a newly developed algorithm may be the key to optimizing alertness with caffeine.

Caffeine is the most widely consumed stimulant to counter the effects of sleep loss on neurobehavioral performance. This study proposed an automated optimization algorithm to identify safe and effective caffeine-dosing strategies that maximize alertness under any sleep-loss condition.

Read the Article

U.S. Army retired Sgt. Maj. Verldon Spence sits and drinks a cup of coffee after a Veterans Day Parade, Nov. 12, 2012. (Credit: Staff Sgt. Kenny Holston)
6 June, 2018 U.S. Army develops algorithm for getting ‘optimal alertness’ from caffeine

But what’s not obvious is when and how much you should consume to achieve the best effects. That’s the focus of a new study funded by the U.S. Army and published in the Journal of Sleep Research.

Caffeine is the most widely used stimulant in the world, consumed in some form by some 90 percent of Americans each day. Studies have shown it reliably boosts performance among sleep-deprived people on cognitive tasks, even after long periods of restricted sleep. The downside is that caffeine, especially high amounts consumed over several days, can prevent sleep-deprived people from making up lost sleep, a measure known as ‘sleep debt’.

Read the Article

Coffee
6 June, 2018 What's the Best Time of Day to Drink Coffee? The U.S. Army Found the Answer

If you love caffeine, you may think there's never a wrong time for coffee, but a new study says there is a right time to get the most out of your daily cup.

Researchers from the United States Army developed an algorithm that makes personal recommendations for timing your caffeine consumption, so you can drink the least amount of coffee to achieve the maximum level of alertness, LiveScience reported.

Read the Article

Coffee brewing - shutterstock
6 June, 2018 Here's How Much Caffeine You Need, and When, for Peak Alertness

Many people groggily pour a cup of coffee in the morning to wake themselves up. But exactly how much caffeine should you consume — and when should you take it — to achieve "peak" alertness?

A new algorithm aims to answer that question.

Read the Article

One cup may be all you need
5 June, 2018 Want to Optimize Your Caffeine Intake? An Army Researcher Created an Algorithm for That

Whether to counter a rough night of sleep, or provide an afternoon jolt, around 90% of Americans consume caffeine in some form every day, according to Villanova University.

However, when and how much caffeine you ingest may impact its effectiveness.

Read the Article

One cup may be all you need
5 June, 2018 The Army wants you... to drink the perfect amount of coffee

Caffeine isn't always as magical as we hope.

We drink cup after cup of coffee to try to finish an important project or remain conscious during perhaps the most tedious meeting ever. Yet it doesn't always turn us into the superheroes of stamina we wish it did.

Read the Article

Young businessman yawning and drinking coffee to be energetic
4 June, 2018 New algorithm determines ideal caffeine dosage and timing for alertness

According to a recent study, a newly developed algorithm may be the key to optimizing alertness with caffeine.

Caffeine is the most widely consumed stimulant to counter the effects of sleep loss on neurobehavioral performance. However, to be safe and most effective, it must be consumed at the right time and in the right amount. This study proposed an automated optimization algorithm to identify safe and effective caffeine-dosing strategies that maximize alertness under any sleep-loss condition.

Read the Article

The US Army has developed an algorithm that can optimize your caffeine consumption to maximize alertness when experiencing sleep loss(Credit: belchonock/Depositphotos)
4 June, 2018 US Army algorithm determines ideal caffeine dosage patterns

How many cups of coffee do you have a day? It's not a stretch to say that caffeine is the world's most popular drug. A recent study found that 85 percent of American adults consume the drug in some form every day, but when and how frequently should we be taking a caffeine hit to get the best effect from it?

Read the Article

News Graphics
4 June, 2018 This Algorithm for how much Caffeine You Should Consume to Wake Yourself up Most Effectively is Research-Based

Drink one cup, still drowsy. Drink more than one cup, you have unmanageable jitters. Anyone who drinks coffee knows the struggle. While you may claim to drink it for the taste, chances are its appeal lies at least in part with its caffeine content. But, like most things, it is hard to know exactly how much you are getting in your morning cup. Beyond that, most coffee drinkers cannot so easily determine how caffeine their bodies need for ideal results to begin with. But, approximation may be a thing of the past thanks to a new algorithm that determines exactly how much caffeine you need, and when to consume it.

Read the Article

News Graphics
4 June, 2018 New algorithm determines ideal caffeine dosage and timing for alertness

According to a recent study, a newly developed algorithm may be the key to optimizing alertness with caffeine.

Caffeine is the most widely consumed stimulant to counter the effects of sleep loss on neurobehavioral performance. However, to be safe and most effective, it must be consumed at the right time and in the right amount. This study proposed an automated optimization algorithm to identify safe and effective caffeine-dosing strategies that maximize alertness under any sleep-loss condition.

Read the Article

Photo of a brewing coffee
4 June, 2018 The US Army’s new algorithm tells you how much caffeine will hit your body’s peak performance

The Army wants you….awake. Since at least WWII, US military scientists have been tinkering with the human brain to keep pilots, soldiers and staff alert despite lack of sleep. Their enemies have as well: The Nazis infamously plied their ranks with methamphetamines (also known as speed).

Read the Article

April 2018

The Web-based server and user interface for the immmunosequencing annotation tool BRILIA, which is available to all DoD vaccine researchers. The B cell lineage map on the right annotates the evolution of vaccine-induced antibody responses from the immunosequencing data.
13 April, 2018 BHSAI Develops Software to Track Antibody Responses to Vaccines

Vaccines are a critical component in maintaining Force Health Protection by providing a first line of defense against infectious diseases or weaponized biological agents. The U.S. Army carries out pre-clinical and clinical vaccine research on a wide range of biological targets, from malaria and dengue fever to Ebola and Anthrax.

Read the Article

Links